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Reductive Acylamination of Pyridine N-Oxide with Aminopyridines and Their N-p-Tolylsulfonyl Derivatives

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Abstract

Pyridine N-oxide reacts with 2- and 3-aminopyridines and their N-p-tolylsulfonyl derivatives in alkaline medium in the presence of p-toluenesulfonyl chloride to give N-p-tolylsulfonyl-2,2′- and 2,3′-dipyridylamines, respectively, as a result of reductive acylamination. In the reactions with 4-aminopyridine and 4-p-tolylsulfonyl-aminopyridine, their N-p-tolylsulfonyl- and N,N-bis(p-tolylsulfonyl) derivatives are formed, while reductive acylamination does not occur.

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Authors and Affiliations

  1. Alisher Navoi Samarkand State University, Universitetskii bul’var 15, Samarkand, 703004, Kazakhstan

    M. A. Solekhova & Yu. V. Kurbatov

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  1. M. A. Solekhova
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  2. Yu. V. Kurbatov
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Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 128–130.

Original Russian Text Copyright © 2005 by Solekhova, Kurbatov.

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Solekhova, M.A., Kurbatov, Y.V. Reductive Acylamination of Pyridine N-Oxide with Aminopyridines and Their N-p-Tolylsulfonyl Derivatives. Russ J Org Chem 41, 128–130 (2005). https://doi.org/10.1007/s11178-005-0134-x

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  • DOI: https://doi.org/10.1007/s11178-005-0134-x

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