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Synthesis of N-Arylsulfonyl-α-thienylglycines from N-(2,2,2-Trichloro-1-thienylethyl)arenesulfonamides

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Abstract

Reactions of N-(2,2,2-trichloroethylidene)arenesulfonamides with thiophene, 2-chlorothiophene, and 2,5-dichlorothiophene, as well as of N-(2,2,2-trichloro-1-hydroxyethyl)arenesulfonamides with 2-chlorothiophene, lead to formation of the corresponding N-(2,2,2-trichloro-1-thienylethyl)arenesulfonamides. Alkaline hydrolysis of the latter occurs selectively at the trichloromethyl group to give N-arylsulfonyl-α-thienylglycines.

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Authors and Affiliations

  1. Favorskii Irkutsk Institute of Chemistry, Siberian Division, Russian Academy of Sciences, ul. Favorskogo 1, Irkutsk, 664033, Russia

    Yu. A. Aizina, I. B. Rozentsveig, I. V. Ushakova, G. G. Levkovskaya & A. N. Mirskova

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  1. Yu. A. Aizina
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  2. I. B. Rozentsveig
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  3. I. V. Ushakova
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  4. G. G. Levkovskaya
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  5. A. N. Mirskova
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__________

Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 93–96.

Original Russian Text Copyright © 2005 by Aizina, Rozentsveig, Ushakova, Levkovskaya, Mirskova.

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Aizina, Y.A., Rozentsveig, I.B., Ushakova, I.V. et al. Synthesis of N-Arylsulfonyl-α-thienylglycines from N-(2,2,2-Trichloro-1-thienylethyl)arenesulfonamides. Russ J Org Chem 41, 91–94 (2005). https://doi.org/10.1007/s11178-005-0126-x

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  • DOI: https://doi.org/10.1007/s11178-005-0126-x

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