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Synthesis and biological activity of new 2-amino-4-[3-methyl-3-(5,6,7,8-tetrahydro-2-naphthyl)cyclobutyl]thiazole derivatives

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Abstract

2-Amino-4-[3-methyl-3-(5,6,7,8-tetrahydro-2-naphthyl)cyclobutyl]thiazole was synthesized by reaction of 1-methyl-1-(5,6,7,8-tetrahydro-2-naphthyl)-3-chloroacetylcyclobutane with thiourea in ethanol, and its subsequent transformations afforded new derivatives which were tested in vitro for antibacterial activity against some bacteria using the disk diffusion technique.

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REFERENCES

  1. Akhmedov, M.A., Mustafaeva, Z.G., Akhmedov, I.M., and Kostikov, R.R., Russ. J. Org. Chem., 1991, vol. 27, p. 1434.

    CAS  Google Scholar 

  2. Coşkun, M., Demirelli, K., and Ahmedzade, M., J. Macromol. Sci. Pure Appl. Chem., 1997, vol. 34, p. 429.

    Google Scholar 

  3. İnce, A., Ahmedov, M.A., Coşkun, M., Cansız, A., and Mete, A., Abstracts of Papers, 10th National Congr. of Chemistry, Bursa, Turkey: Univ. of Uludağ, 1994, p. 300.

    Google Scholar 

  4. Beyer, H., Organic Chemistry, Frankfurt-um-Main: Harry Deutsch, 1963.

    Google Scholar 

  5. Ibatullin, U.G., Petrushina, T.F., Leitis, L.Ya., Minibaev, I.Z., and Logvin, B.O., Khim. Geterotsikl. Soedin.; Chem. Abstr., 1994, vol. 120, p. 1145.

    Google Scholar 

  6. Roger, E., Pierre, C.J., Pualette, V., Gerard, G., Chepat, J.P., and Robert, G., Eur. J. Med. Chem., 1977, vol. 12, p. 501.

    Google Scholar 

  7. Gerard, G., Eur. J. Med. Chem., 1979, vol. 14, p. 493.

    Google Scholar 

  8. Dehmion, E.V. and Schmidt, S.S., Justus Liebigs Ann. Chem., 1990, p. 411.

  9. Foerster, H., Hofer, W., Mues, V., Eue, L., and Schmidt, R.R., FRG Patent no. 2 822 155, 1979.

  10. Sawhney, S.N., Arora, S.K., and Sing, J.V., Indian J. Chem., Sect. B, 1978, vol. 16, p. 605.

    Google Scholar 

  11. Brown, K., Cater, D.P., Cavalla, J.F., Green, D., Newberry, R.A., and Wilson, A.B., J. Med. Chem., 1974, vol. 14, p. 177.

    Google Scholar 

  12. Suzuki, N., Tanaka, Y., and Dohmori, R., Chem. Pharm. Bull., 1979, vol. 27, p. 1.

    CAS  PubMed  Google Scholar 

  13. Slip, P.I., Closier, M., and Neville, M., J. Med. Chem., 1974, vol. 17, p. 207.

    PubMed  Google Scholar 

  14. Capron, A. and Dessaint, J.P., Ann. Rev. Immunol., 1985, vol. 3, p. 455.

    CAS  Google Scholar 

  15. Boedmg, E. and Peters, J.P., J. Pharmacol., 1951, vol. 101, p. 210.

    Google Scholar 

  16. Ebeid, M.N., El-Ansary, A., Kamel, M.M., Kasem, E.M., Abdou, W.A., and Zayed, N., Bull. Fac. Pharm. Cairo Univ., 1992, vol. 30, p. 293.

    CAS  Google Scholar 

  17. Nusle, W., Perkins, G.W., and Toennies, G., Am. J. Pharm., 1935, vol. 107, p. 29.

    Google Scholar 

  18. Bushby, S.R., Catterall, R., and Williamson, M., Brit. Med. J., 1955, vol. 1, p. 78.

    Google Scholar 

  19. Bağcı, E. and Dığrak, M., Flavour Fragr. J., 1996, vol. 11, p. 251.

    Google Scholar 

  20. Bradshaw, L.J., Laboratory Microbiology, Fort Worth: Saunders College, 1992, 4th ed.

    Google Scholar 

  21. Collins, C.H., Lyne, P.M., and Grange, J.M., Microbiological Methods, London: Butterworths, 1989, 6th ed.

    Google Scholar 

  22. Dığrak, M., Alma, M.H., Ilcim, A., and Sen, S., Turkish J. Biol., 1999, vol. 23, p. 241.

    Google Scholar 

  23. Cansız, A., Servi, S., Koparır, M., Altıntaş, M., and Dığrak, M., J. Chem. Soc. Pak., 2001, vol. 23, p. 234.

    Google Scholar 

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Authors and Affiliations

  1. Chemistry Department, Faculty of Arts and Sciences, Fırat University, Elazığ, 23119, Turkey

    M. Koparır, A. Cansız & M. Ahmedzade

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  1. M. Koparır
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  2. A. Cansız
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  3. M. Ahmedzade
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__________

From Zhurnal Organicheskoi Khimii, Vol. 40, No. 12, 2004, pp. 1861–1865.

Original English Text Copyright © 2004 by Koparır, Cansız, Ahmedzade.

The original article was submitted in English.

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Koparır, M., Cansız, A. & Ahmedzade, M. Synthesis and biological activity of new 2-amino-4-[3-methyl-3-(5,6,7,8-tetrahydro-2-naphthyl)cyclobutyl]thiazole derivatives. Russ J Org Chem 40, 1813–1818 (2004). https://doi.org/10.1007/s11178-005-0105-2

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  • DOI: https://doi.org/10.1007/s11178-005-0105-2

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