Abstract
The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 102), Tuvinians (n = 50), and HIV-infected individuals (n = 107) were examined for the presence of CCR5del32 mutation in the CCR5 gene. The CCR5del32 allele frequency in Russians and Tuvinians constituted 7.84 and 2%, respectively. Among HIV-1 infected individuals, two groups, of macrophage-tropic HIV-1 strain- and T-cell-tropic HIV-1 strain-infected were distinguished. The CCR5del32 allele frequency in the first group (6.45%) was lower than in the second one (8.73%). Statistical treatment of the HIV-1 infected individuals typing data showed that the difference in the CCR5del32 allele frequencies between the groups of sexually (macrophage-tropic) and parenterally (T-cell-tropic) infected individuals observed was within the limit of random deviation.
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Translated from Genetika, Vol. 41, No. 11, 2005, pp. 1559–1562.
Original Russian Text Copyright © 2005 by Apryatin, Rakhmanaliev, Nikolaeva, Ruban, Vazykhova, Klimov, Sulimova, Sidorovich.
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Apryatin, S.A., Rakhmanaliev, E.R., Nikolaeva, I.A. et al. Comparison CCR5del32 Mutation in the CCR5 Gene Frequencies in Russians, Tuvinians, and in Groups of HIV-Infected Individuals. Russ J Genet 41, 1287–1290 (2005). https://doi.org/10.1007/s11177-005-0230-6
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DOI: https://doi.org/10.1007/s11177-005-0230-6