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Genomic dosages of active rRNA genes in coke-oven workers

  • Human Genetics
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Abstract

Genomic dosage (copy number) of active ribosomal genes was evaluated using visual semi-quantitative method determining the sizes of Ag-NORs in acrocentric chromosomes after selective silver nitrate staining. A relationship between the length of service and the active ribosomal gene copy number was established: the highest numbers of active rRNA genes were observed in coke-oven workers with a length of service exceeding 20 years. An inverse relationship between the individual doses of active ribosomal genes and toxicogenetic susceptibility of the workers to the occupational factors was also revealed.

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  1. Department of Genetics, Kemerovo State University, 650043, Kemerovo, Russia

    V. I. Minina & V. G. Druzhinin

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  1. V. I. Minina
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  2. V. G. Druzhinin
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Translated from Genetika, Vol. 40, No. 12, 2004, pp. 1702–1708.

Original Russian Text Copyright © 2004 by Minina, Druzhinin.

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Minina, V.I., Druzhinin, V.G. Genomic dosages of active rRNA genes in coke-oven workers. Russ J Genet 40, 1413–1418 (2004). https://doi.org/10.1007/s11177-005-0013-0

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  • DOI: https://doi.org/10.1007/s11177-005-0013-0

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