Abstract
Zinc enolates generated from 1-aryl-2-bromoalkanones and zinc react with dimethyl 2-(1-arylmethylene)malonate to form dimethyl 2-(2-alkyl-1,3-diaryl-3-oxopropyl)malonates. The latter react with benzylamine or cyclohexylamine to form the corresponding disubstituted amides, while the reactions with piperidine, morpholine, and p-methoxyaniline provide monosubstituted amides of the corresponding target derivatives.
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Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 4, 2005, pp. 636–641.
Original Russian Text Copyright © 2005 by Shchepin, Korzun, Poroshina.
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Shchepin, V.V., Korzun, A.E. & Poroshina, N.Y. Synthesis of Dimethyl 2-(2-Alkyl-1,3-diaryl-3-oxopropyl)malonates and Their Reactions with Amines. Russ J Gen Chem 75, 597–604 (2005). https://doi.org/10.1007/s11176-005-0279-x
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DOI: https://doi.org/10.1007/s11176-005-0279-x