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Convenient Synthetic Approach to (2-Aryl-5-phenyl-1,3-oxazol-4-yl)phosphonic Acids and Their Functional Derivatives

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Abstract

Successive treatment of available amidophenacylating agents of the general formula PhCOCH ⋅ ClNHCOAr with trimethyl phosphite and phosphorus pentachloride gave previously unknown (2-aryl-5-phenyl-1,3-oxazol-4-yl)phosphonic dichlorides which are suitable dtarting materials for preparing other phosphorylated oxazoles containing P(O)(OH)2, P(O)(NHAlk)2, P(O)(OMe)NHAlk, P(O)(OMe)NAlk2, and other groups in the 4 position of the heteroring.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine

    A. G. Belyuga, V. S. Brovarets & B. S. Drach

Authors
  1. A. G. Belyuga
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  2. V. S. Brovarets
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  3. B. S. Drach
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__________

Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 4, 2005, pp. 561–564.

Original Russian Text Copyright © 2005 by Belyuga, Brovarets, Drach.

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Belyuga, A.G., Brovarets, V.S. & Drach, B.S. Convenient Synthetic Approach to (2-Aryl-5-phenyl-1,3-oxazol-4-yl)phosphonic Acids and Their Functional Derivatives. Russ J Gen Chem 75, 523–526 (2005). https://doi.org/10.1007/s11176-005-0265-3

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  • DOI: https://doi.org/10.1007/s11176-005-0265-3

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