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Synthesis of phosphinic acids on the basis of hypophosphites: IV. Synthesis of pseudo-γ-glutamylglycine and its enantiomers

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Abstract

A new method for construction of pseudopeptide molecules is proposed, exemplified by the synthesis of [3-amino-3-(hydroxycarbonyl)propyl][2-(hydroxycabonyl)ethyl]phosphinic acid (I) (pseudo-γ-glutamylglycine), starting from ammonium hypophosphite. Enzymatic synthesis using immobilized penicillamidase allowed preparation of the enantiomers of acid I.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia

    V. V. Ragulin

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  1. V. V. Ragulin
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Translated from Zhurnal Obshchei Khimii, Vol. 74, No. 8, 2004, pp. 1273–1278.

Original Russian Text Copyright © 2004 by Ragulin.

For communication III, see [1].

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Ragulin, V.V. Synthesis of phosphinic acids on the basis of hypophosphites: IV. Synthesis of pseudo-γ-glutamylglycine and its enantiomers. Russ J Gen Chem 74, 1177–1181 (2004). https://doi.org/10.1007/s11176-005-0133-1

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  • DOI: https://doi.org/10.1007/s11176-005-0133-1

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