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Phosphorus pentasulfide and Lawesson reagent in synthesis of 1,3-thiazole-4-thiol derivatives

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Abstract

Available S-amidophenacylation products of thiols and sulfanylphenols on treatment with phosphorus pentasulfide or, which is better, Lawesson reagent convert into the corresponding 1,3-thiazole-4-thiol derivatives that are easily oxidized with hydrogen peroxide. The latter reaction was used to introduce a series of alkyl- or arylsulfonyl groups in the 4 position of the thiazole ring. This general approach significantly extends the limited range of synthetic procedures for 1,3-thiazole-4-thiol derivatives.

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Authors and Affiliations

  1. Institute of Bioorganic and Oil Chemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine

    A. G. Belyuga, V. S. Brovarets & B. S. Drach

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  1. A. G. Belyuga
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  2. V. S. Brovarets
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  3. B. S. Drach
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Translated from Zhurnal Obshchei Khimii, Vol. 74, No. 9, 2004, pp. 1529–1533.

Original Russian Text Copyright © 2004 by Belyuga, Brovarets, Drach.

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Belyuga, A.G., Brovarets, V.S. & Drach, B.S. Phosphorus pentasulfide and Lawesson reagent in synthesis of 1,3-thiazole-4-thiol derivatives. Russ J Gen Chem 74, 1418–1422 (2004). https://doi.org/10.1007/s11176-005-0024-5

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  • DOI: https://doi.org/10.1007/s11176-005-0024-5

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