Abstract
New structural analogs of cystathionine-γ-lyase blockers described earlier in the literature, probable synergists of antibiotics, were developed, synthesized, and studied for biological properties. According to the results of biological assays, the introduction of the 1,3,4-oxadiazole moiety into the molecules of test compounds deprives them of the target type of activity. In addition, the specified type of biological activity was not confirmed in one of the prototype compounds.
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Funding
This study was financially supported by the Ministry of Science and Higher Education of the Russian Federation (agreement No. 075-10-2021-113, unique project identifier RF-193021X0001) and was performed using the equipment of the resource center for medicinal chemistry of the Autonomous NonCommercial Organization of Higher Education, National Technical University, Sirius.
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No human or animal subjects were used in this research.
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The authors declare no competing interests.
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Dedicated to Academician of the Russian Academy of Sciences M. P. Egorov on the occasion of his 70th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 73, No. 1, pp. 204–212, January, 2024.
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Golovina, A.V., Al’mukhametov, A.Z., Kasatkina, M.A. et al. Inhibitors of bacterial cystathionine γ-lyase as antibiotic synergists Part 1. Functional derivatives of 1,3,4-oxadiazole-2-carboxylic acid: synthesis and biological activity. Russ Chem Bull 73, 204–212 (2024). https://doi.org/10.1007/s11172-024-4132-y
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DOI: https://doi.org/10.1007/s11172-024-4132-y