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Synthesis of derivatives of 6-aryl-2,2′-bipyridine complexes with PtII as potential antitumor agents

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Abstract

New PtII complexes of aryl- and diaryl-2,2′-bipyridines were prepared using the Kröhnke method for the further synthesis of pyridine derivatives. Signal assignment in the 1H and 13C NMR spectra was performed for the 1D and 2D NMR spectral data. The primary screening evaluation of the antitumor activity of the synthesized compounds on cultured human cells in vitro showed high biological significance of selected samples. The cell death under the action of the studied compounds proceeds via apoptosis type as shown by fluorescent dyeing and polymerase chain reaction in the real time.

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Funding

This work was financially supported by the Russian Science Foundation (Project No. 23-23-00375).

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Authors and Affiliations

  1. Chemical Technology Institute, Ural Federal University named after the first President of Russia B. N. Yeltsin, 28 ul. Mira, 620002, Yekaterinburg, Russian Federation

    V. M. Abramov, L. A. Cheremnykh, O. S. El’tsov, M. D. Tokhtueva, V. V. Melekhin, A. V. Paramonova, A. A. Mezentseva & A. E. Chernysheva

  2. Ural State Medical University, 17 ul. Klyuchevskaya, 620109, Yekaterinburg, Russian Federation

    V. V. Melekhin & O. G. Makeev

Authors
  1. V. M. Abramov
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  2. L. A. Cheremnykh
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  3. O. S. El’tsov
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  4. M. D. Tokhtueva
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  5. V. V. Melekhin
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  6. A. V. Paramonova
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  7. A. A. Mezentseva
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  8. A. E. Chernysheva
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  9. O. G. Makeev
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Corresponding author

Correspondence to O. S. El’tsov.

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Animal Testing and Ethics

No human or animal subjects were used in this research.

Conflict of Interest

The authors declare no competing interests.

Additional information

Based on the materials of the VII International Conference “Modern Synthetic Methodologies for Creating Drugs and Functional Materials” (MOSM 2023) dedicated to the 125th birth anniversary of Academician I. Ya. Postovsky (September 10–16, 2023, Yekaterinburg–Perm, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 12, pp. 2848–2859, December, 2023.

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Abramov, V.M., Cheremnykh, L.A., El’tsov, O.S. et al. Synthesis of derivatives of 6-aryl-2,2′-bipyridine complexes with PtII as potential antitumor agents. Russ Chem Bull 72, 2848–2859 (2023). https://doi.org/10.1007/s11172-023-4094-5

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  • DOI: https://doi.org/10.1007/s11172-023-4094-5

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