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Structure, 1H and 13C NMR spectra of the minor component from the antimicrobial complex produced by actinomycete Streptomyces roseoflavus (INA-Ac-5812)

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Abstract

The antibiotics INA-5812, produced by the strain INA-Ac-5812 of Streptomyces roseoflavus have pronounced antibacterial and chemotherapeutic activity and low value of acute toxicity. The minor component of the complex was isolated from the culture liquid by extraction with organic solvents and purified by chromatographic methods. Its structure was established by mass spectrometry and 1H and 13C NMR spectroscopy.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    D. E. Tsvetkov, A. O. Chizhov, A. S. Dmitrenok & N. E. Nifantiev

  2. G. F. Gause Research Institute of New Antibiotics, 11 ul. Bol’shaya Pirogovskaya, 119021, Moscow, Russian Federation

    O. A. Lapchinskaya & G. S. Katrukha

Authors
  1. D. E. Tsvetkov
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  2. A. O. Chizhov
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  3. A. S. Dmitrenok
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  4. O. A. Lapchinskaya
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  5. G. S. Katrukha
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  6. N. E. Nifantiev
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Corresponding author

Correspondence to N. E. Nifantiev.

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No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 9, pp. 2197–2205, September, 2023.

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Tsvetkov, D.E., Chizhov, A.O., Dmitrenok, A.S. et al. Structure, 1H and 13C NMR spectra of the minor component from the antimicrobial complex produced by actinomycete Streptomyces roseoflavus (INA-Ac-5812). Russ Chem Bull 72, 2197–2205 (2023). https://doi.org/10.1007/s11172-023-4016-6

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  • DOI: https://doi.org/10.1007/s11172-023-4016-6

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