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Synthesis of 3-hydroxy-1H-pyrroles and pyridazines with a sterically hindered phenol moiety

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Abstract

Novel pyrroles and pyridazines were obtained by the reaction of (4-hydroxy-3,5-di-tert-butylphenyl)glyoxal with 1,3-diketones and ammonium acetate or hydrazine hydrate. The study of antioxidant activity of the synthesized compounds using ABTS and PFRAP tests showed that 7-thoxo-7,8-dihydropyrimido[4,5-c]pyridazin-5(6H)-one has the highest activity.

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Authors and Affiliations

  1. National University of Oil and Gas “Gubkin University”, 65 Leninsky prosp., 119991, Moscow, Russian Federation

    K. V. Ilkov, A. A. Gladkikh & V. N. Koshelev

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  1. K. V. Ilkov
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  2. A. A. Gladkikh
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  3. V. N. Koshelev
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Correspondence to K. V. Ilkov.

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The authors declare no competing interests.

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No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 9, pp. 2119–2124, September, 2023.

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Ilkov, K.V., Gladkikh, A.A. & Koshelev, V.N. Synthesis of 3-hydroxy-1H-pyrroles and pyridazines with a sterically hindered phenol moiety. Russ Chem Bull 72, 2119–2124 (2023). https://doi.org/10.1007/s11172-023-4006-8

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  • DOI: https://doi.org/10.1007/s11172-023-4006-8

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