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Synthesis and antibacterial evaluation of alkaloid-like phenylfuroacridones

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Abstract

A number of new alkaloid-like phenylfuroacridones were synthesized by cyclization in polyphosphoric acid of 2-, 3 -, 4-(2-oxo-2-phenylethoxy)acridones, which, in turn, were obtained by O-alkylation of the corresponding 2-, 3-, 4-hydroxyacridones with phenacyl bromide. Biological studies showed that phenylfuroacridones exhibited a low antibacterial activity against the test strain Candida albicans.

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Authors and Affiliations

  1. Kursk State University, 33 ul. Radishcheva, 305000, Kursk, Russian Federation

    T. A. Kudryavtsev, T. N. Kudryavtseva, V. E. Melnichenko, A. Yu. Lamanov & L. G. Klimova

  2. Kursk State Medical University, 3 ul. Karla Marksa, 305000, Kursk, Russian Federation

    L. G. Klimova

Authors
  1. T. A. Kudryavtsev
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  2. T. N. Kudryavtseva
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  3. V. E. Melnichenko
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  4. A. Yu. Lamanov
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  5. L. G. Klimova
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Correspondence to T. A. Kudryavtsev.

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The authors declare no competing interests.

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No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 8, pp. 1953–1956, August, 2023.

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Kudryavtsev, T.A., Kudryavtseva, T.N., Melnichenko, V.E. et al. Synthesis and antibacterial evaluation of alkaloid-like phenylfuroacridones. Russ Chem Bull 72, 1953–1956 (2023). https://doi.org/10.1007/s11172-023-3985-9

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  • DOI: https://doi.org/10.1007/s11172-023-3985-9

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