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Interaction of acetylcholine with biodegradable biopolyesters and catalysis of the radical decomposition of hydroperoxides in solutions

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Abstract

Biopolymers incorporating biologically active compounds are promising for applications in regenerative medicine and controlled drug delivery. We have studied the interaction of the neurotransmitter acetylcholine (ACh) with biocompatible polymers, polylactide (PLA), poly-3-hydroxybutyrate (PHB), and poly-ε-caprolactone (PCL). Analysis of particle sizes and zeta potentials in solutions in chloroform by dynamic light scattering showed that the addition of 1 mmol L−1 of ACh to polymer solutions led to a decrease in the size of globules and a decrease in the zeta potential, which indicated a polymer—ACh interaction. Individual PLA, PCL, PHB, and ACh dissolved in chloroform accelerated the radical decomposition of hydroperoxides, and synergism in the generation of radicals was observed in a mixture of polymers with ACh.

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References

  1. C. Zhu Peter, New Biocides Development. The Combined Approach of Chemistry and Microbiology, ACS Symposium Series, 2008, 967, 520.

    Google Scholar 

  2. D. Kwaśniewska, Y.-L. Chen, D. Wieczorek, Pathogens, 2020, 9, 459; DOI: https://doi.org/10.3390/pathogens9060459.

    Article  PubMed  PubMed Central  Google Scholar 

  3. A. N. Vereshchagin, N. A. Frolov, K. S. Egorova, M. M. Seitkalieva, V. P. Ananikov, Int. J. Mol. Sci., 2021, 22, 6793; DOI: https://doi.org/10.3390/ijms22136793.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Z. A. Al-Shareeda, R. A. Abramovich, O. G. Potanina, H. Alhejoj, Int. J. Pharm. Qual. Assur., 2020, 11, 361.

    Article  Google Scholar 

  5. M. A. Cox, C. Bassi, M. E. Saunders, R. Nechanitzky, I. Morgado-Palacin, C. Zheng, T. W. Mak, J. Int. Med., 2020, 287, 120; DOI: https://doi.org/10.1111/joim.13006.

    Article  CAS  Google Scholar 

  6. N. V. Potapova, O. T. Kasaikina, M. P. Berezin, I. G. Plashchina, Kinetics and Catalysis, 2020, 61, 786–791; DOI: https://doi.org/10.1134/S0023158420050079.

    Article  CAS  Google Scholar 

  7. O. T. Kasaikina, N. V. Potapova, D. A. Krugovov, I. G. Plashchina, Russ. Chem. Bull., 2018, 67, 2141; DOI: https://doi.org/10.1007/s11172-018-2342-x.

    Article  CAS  Google Scholar 

  8. N. V. Potapova, D. A. Krugovov, O. T. Kasaikina, Bulg. Chem. Commun. Special Issue C, 2018, 50, 275.

    Google Scholar 

  9. O. T. Kasaikina, N. V. Potapova, D. A. Krugovov, M. P. Berezin, Polym. Sci., Ser. B, 59, 181.

  10. P. Zahedi, I. Rezaeian, S.-O. Ranaei-Siadat, S.-H. Jafari, P. Supaphol, Polym. Adv. Technologies, 2009, 21, 77–95; DOI: https://doi.org/10.1002/pat.1625.

    Article  Google Scholar 

  11. H.-S. Wang, G.-D. Fu, X.-S. Li, Rec. Pat. Nanotechnol., 2009, 3, 21.

    Article  Google Scholar 

  12. K. Joung, J. W. Bae, K. D. Park, Expert Opin. Drug Deliv., 2008, 5, 1173.

    Article  CAS  PubMed  Google Scholar 

  13. N. B. Svishcheva, P. A. Khaptakhanova, D. A. Kasatov, S. A. Uspensky, Russ. Chem. Bull., 2021, 70, 1725; DOI: https://doi.org/10.1007/s11172-021-3276-2.

    Article  CAS  Google Scholar 

  14. Yu. N. Filatov, Elektroformovanie voloknistykh materialov (EFV-protsess) [Electrospinning of Fibrous Materials (ESF Process)], Neft’ i Gas, Moscow, 2001, 231 pp. (in Russian).

    Google Scholar 

  15. A. A. Ol’khov, S. G. Karpova, P. M. Tyubaeva, A. L. Zhul’kina, Yu. N. Zernova, A. L. Iordansky, Perspektivnye materialy [Advanced Materials], 2020, 3, 28; DOI: https://doi.org/10.30791/1028-978X-2020-3-28-37.

    Article  Google Scholar 

  16. N. A. Trunova, Z. S. Kartasheva, T. V. Maksimova, Y. P. Bogdanova, O. T. Kasaikina, Colloid J., 2007, 69, 697.

    Article  Google Scholar 

  17. P. Dhar, U. Bhardwaj, A. Kumar, V. Katiyar, Polym. Engl. Sci., 2015, 55, 2388; DOI: https://doi.org/10.1002/pen.24127.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. N. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Korp. 1, 4 ul. Kosygina, 119991, Moscow, Russian Federation

    N. V. Potapova, O. T. Kasaikina, A. A. Olkhov & A. L. Iordanskii

  2. G. V. Plekhanov Russian University of Economics, 36 Stremyannoy per., 117997, Moscow, Russian Federation

    A. A. Olkhov

  3. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 119991, Moscow, Russian Federation

    I. G. Plashchina

Authors
  1. N. V. Potapova
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  2. O. T. Kasaikina
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  3. A. A. Olkhov
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  4. A. L. Iordanskii
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  5. I. G. Plashchina
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Corresponding author

Correspondence to N. V. Potapova.

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The authors declare no competing interests.

Additional information

This work was financially supported by the Russian Foundation for Basic Research (Project No. 20-03-00753) and within the framework of the Russian state assignment of the Federal Agency for Scientific Organizations (FASO) of Russia (No. 122040500074-1).

No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 8, pp. 1942–1945, August, 2023.

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Potapova, N.V., Kasaikina, O.T., Olkhov, A.A. et al. Interaction of acetylcholine with biodegradable biopolyesters and catalysis of the radical decomposition of hydroperoxides in solutions. Russ Chem Bull 72, 1942–1945 (2023). https://doi.org/10.1007/s11172-023-3982-z

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  • DOI: https://doi.org/10.1007/s11172-023-3982-z

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