Abstract
A one-pot process involving dehydration of cyclohexanol affording cyclohexene followed by alkoxycarbonylation of the latter with cyclohexanol and CO catalyzed by the PdCl2-PPh3-p-toluenesulfonic acid system was carried out. The yield of the target product, cyclohexyl cyclohexanecarboxylate, was as high as 74.8% after 6 h at 115 °C and at a reactor pressure of 2.1 MPa. In the presence of the offered catalytic system, the process proceeds under mild conditions using available reagents without isolation and purification of the intermediate product, cyclohexene.
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This work was financially supported by the Russian Science Foundation (Project No. 22-23-00102, https://rscf.ru/project/22-23-00102/).
No human or animal subjects were used in this research.
Based on the materials of the VI International Conference “Modern Synthetic Methodologies for Creating Drugs and Functional Materials” (MOSM 2022) (November 7–11, 2022, Ekaterinburg, Russia).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 8, pp. 1936–1939, August, 2023.
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Sevostyanova, N.T., Batashev, S.A. & Rodionova, A.S. One-pot process involving dehydration of cyclohexanol and alkoxycarbonylation of cyclohexene in the presence of catalytic system PdCl2-PPh3-p-toluenesulfonic acid. Russ Chem Bull 72, 1936–1939 (2023). https://doi.org/10.1007/s11172-023-3980-1
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DOI: https://doi.org/10.1007/s11172-023-3980-1