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Effect of phospholipids on the inhibitory efficiency of natural and synthetic antioxidants in oxidation processes

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Abstract

Experimental results on the effect of phospholipids (l-α-phosphatidylcholine, dipal-mitoylphosphatidylcholine, egg yolk lecithin; soybean lecithin) on the inhibitory efficiency of 20 antioxidants (AOs) are summarized depending on the structure and kinetic parameters of AOs in reactions with free peroxyl radicals and the composition of phos-pholipids. The reactivity of AOs and their mixtures with phospholipids was evaluated using three model systems: the initiated oxidation of ethylbenzene and methyl oleate (kinetic oxidation region) and the autooxidation of neat methyl oleate in a free-air exposure system (diffusive oxidation region). For the most part, the addition of phospholipids leads to a change in the antiradical and antioxidant activity of AOs and in the initial oxidation rate due to the complexation between AOs and phospholipids (confirmed by UV and IR spectroscopy) and the effect of AOs on the ability of phospholipids to self-aggregate (demonstrated by dynamic light scattering). This effect depends on the structure of AOs, their ability to be involved in side reactions, the phospholipid composition, the polarity of the medium, and the intensity of oxidation processes. The obtained data and the literature analysis demonstrate that it is necessary to investigate in detail the mechanism of interrelations between AOs and phospholipids, which are the main components of biological membranes, in order to obtain an adequate preliminary evaluation of the most promising newly synthesized compounds for practical use.

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Authors and Affiliations

  1. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 119334, Moscow, Russian Federation

    L. N. Shishkina, L. I. Mazaletskaya, M. V. Kozlov & N. I. Sheludchenko

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  1. L. N. Shishkina
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  2. L. I. Mazaletskaya
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  3. M. V. Kozlov
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  4. N. I. Sheludchenko
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Correspondence to L. N. Shishkina.

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Additional information

We are grateful to Academician of the Russian Academy of Sciences A. V. Kuchin, I. Yu. Chukicheva, and I. V. Fedorova for providing IBP samples for investigations.

This study was performed within the state assignment for the N. M. Emanuel Institute of Biochemical Physics (IBCP) of the Russian Academy of Sciences (section 44.4, registration number 0084-2019-0014) using the equipment of the Core Facility “New Materials and Technologies” of the IBCP.

No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 8, pp. 1876–1886, August, 2023.

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Shishkina, L.N., Mazaletskaya, L.I., Kozlov, M.V. et al. Effect of phospholipids on the inhibitory efficiency of natural and synthetic antioxidants in oxidation processes. Russ Chem Bull 72, 1876–1886 (2023). https://doi.org/10.1007/s11172-023-3972-1

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  • DOI: https://doi.org/10.1007/s11172-023-3972-1

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