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Synthesis of 6-methyluracil-5-carboxaldehyde hydrazones

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Abstract

A series of hydrazones bearing 6-methyluracil and hydrazone pharmacophoric units were synthesized by the direct reaction of 6-methyluracil-5-carboxaldehyde and either carboxylic acid hydrazides or hydrazines. It was found that E configuration of the C=N double bond is preferable for some of the synthesized compounds.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences, 71 prosp. Oktyabrya, 450054, Ufa, Russian Federation

    I. B. Chernikova, E. R. Belyaeva & A. N. Lobov

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  1. I. B. Chernikova
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  2. E. R. Belyaeva
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  3. A. N. Lobov
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Correspondence to I. B. Chernikova.

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The authors declare no competing interests.

Additional information

This work was performed in the framework of the State Task of the Ministry of Science and Higher Education of the Russian Federation (Topic No. 122031400260-7 (synthesis of hydrazones), No. 122031400275-1 (synthesis of acyl hydrazides), and No. 122031400282-9 (spectral studies)). Spectral studies were carried out on the equipment of the User Service Center “Chemistry” at the Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences.

This paper does not contain descriptions of studies on animals or humans.

Published in Russian in Izyestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 8, pp. 1815–1820, August, 2023.

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Chernikova, I.B., Belyaeva, E.R. & Lobov, A.N. Synthesis of 6-methyluracil-5-carboxaldehyde hydrazones. Russ Chem Bull 72, 1815–1820 (2023). https://doi.org/10.1007/s11172-023-3964-1

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  • DOI: https://doi.org/10.1007/s11172-023-3964-1

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