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Intramolecular reductive Heck reaction in the synthesis of 3,3-disubstituted isoindolin-1-ones

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Russian Chemical Bulletin Aims and scope

Abstract

An efficient approach to the synthesis of 3,3-disubstituted isoindolinones by intramolecular cyclization of enamides in the presence of the Pd(OAc)2/Ph3P catalytic system and sodium formate as a reducing agent was suggested.

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Authors and Affiliations

  1. Samara State Technical University, 244 ul. Molodogvardeyskaya, 443100, Samara, Russian Federation

    M. A. Ashatkina, A. N. Reznikov, S. Yu. Vostrukhina, D. S. Nikerov & Yu. N. Klimochkin

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  1. M. A. Ashatkina
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  2. A. N. Reznikov
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  3. S. Yu. Vostrukhina
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  4. D. S. Nikerov
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  5. Yu. N. Klimochkin
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Corresponding author

Correspondence to A. N. Reznikov.

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The authors declare no competing interests.

Additional information

This work was financially supported by the Russian Science Foundation (Project No. 21-73-20096). Spectral studies of the synthesized compounds were performed with the financial support from the Ministry of Science and Higher Education of the Russian Federation in the framework of the basic part of the State Task (No. FSSE-2023-0003).

No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 8, pp. 1809–1814, August, 2023.

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Ashatkina, M.A., Reznikov, A.N., Vostrukhina, S.Y. et al. Intramolecular reductive Heck reaction in the synthesis of 3,3-disubstituted isoindolin-1-ones. Russ Chem Bull 72, 1809–1814 (2023). https://doi.org/10.1007/s11172-023-3963-2

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  • DOI: https://doi.org/10.1007/s11172-023-3963-2

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