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Synthesis of [4-(3-aryl-1,2,4-oxadiazol-5-ylmethylthio)-2-methylphenoxy]acetic acids as new potential PPAR agonists

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Abstract

A five-step synthetic route to [4-(3-aryl-1,2,4-oxadiazol-5-ylmethylthio)-2-methyl-phenoxy]acetic acids, new potential agonists of type δ/β peroxisome proliferator-activated receptors (PPARδ/β), starting from substituted benzonitriles was developed.

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Authors and Affiliations

  1. Mendeleev University of Chemical Technology, 9 Miusskaya pl., 125047, Moscow, Russian Federation

    D. V. Minin, S. V. Popkov, K. V. Pesochinskaya & D. R. Aleksanov

Authors
  1. D. V. Minin
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  2. S. V. Popkov
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  3. K. V. Pesochinskaya
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  4. D. R. Aleksanov
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Corresponding author

Correspondence to D. V. Minin.

Additional information

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 7, pp. 1648–1653, July, 2023.

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Minin, D.V., Popkov, S.V., Pesochinskaya, K.V. et al. Synthesis of [4-(3-aryl-1,2,4-oxadiazol-5-ylmethylthio)-2-methylphenoxy]acetic acids as new potential PPAR agonists. Russ Chem Bull 72, 1648–1653 (2023). https://doi.org/10.1007/s11172-023-3944-5

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  • DOI: https://doi.org/10.1007/s11172-023-3944-5

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