Abstract
Water-soluble spin probes were obtained from reduction-resistant sterically shielded pyrrolidine nitroxides by forming a 4,5-dicarboxy-1H-1,2,3-triazole fragment in the side chain by the Huisgen reaction of the azido group with acetylenedicarboxylic acid ester followed by hydrolysis. For the synthesized radicals, the reduction rate constants by ascorbate and the partition coefficient in an octanol—water system were determined.
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The authors are grateful to the stuff of the Chemical Research Center of the Collective Use at the Siberian Branch of the Russian Academy of Sciences for the spectral and analytical measurements.
This work was financially supported by the Russian Science Foundation (Project No. 21-73-00281).
No human or animal subjects were used in this research.
The authors declare no competing interests.
Based on the materials of the All-Russian Conference “Markovnikov Readings: Organic Chemistry from Markovnikov to the Present Day” (WSOC 2022) (September 16–21, 2022, Sochi).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 7, pp. 1569–1575, July, 2023.
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Trakhinina, S.Y., Taratayko, A.I., Glazachev, Y.I. et al. Sterically shielded pyrrolidine nitroxides with 3-(4,5-dicarboxy-1H-1,2,3-triazol-1-yl)propyl substituent. Russ Chem Bull 72, 1569–1575 (2023). https://doi.org/10.1007/s11172-023-3935-6
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DOI: https://doi.org/10.1007/s11172-023-3935-6