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One-pot synthesis of 2H-thiopyrans from β-amino enones

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Abstract

A one-pot synthesis of 2H-thiopyrans from β-amino enones has been developed. Sequential treatment of β-amino enones with the Lawesson’s reagent and electron-deficient dienophiles (maleic anhydride and maleimides) in dichloromethane gave 2H-thiopyran derivatives in 25—62% yields.

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Authors and Affiliations

  1. Yaroslavl State Technical University, 88 Moskovskii prosp., 150999, Yaroslavl, Russian Federation

    I. D. Karpov, K. L. Ovchinnikov & A. V. Kolobov

Authors
  1. I. D. Karpov
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  2. K. L. Ovchinnikov
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  3. A. V. Kolobov
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Corresponding author

Correspondence to K. L. Ovchinnikov.

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No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 5, pp. 1279–1282, May, 2023.

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Karpov, I.D., Ovchinnikov, K.L. & Kolobov, A.V. One-pot synthesis of 2H-thiopyrans from β-amino enones. Russ Chem Bull 72, 1279–1282 (2023). https://doi.org/10.1007/s11172-023-3902-2

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  • DOI: https://doi.org/10.1007/s11172-023-3902-2

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