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Chemo-enzymatic synthesis of (S,S)-2,2′-(ethylenediamino)dibutan-1-ol

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Abstract

A chemo-enzymatic method is proposed for the preparation of (S,S)-2,2′-(ethylenediamino)dibutan-1-ol based on the synthesis of racemic (±)-N-carbobenzoxy-2-amino-butan-1-ol and its enantioselective acylation in the presence of lipase at a key resolution step to release the optically active alcohol.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement compounds, Russian Academy of Sciences, Build. 1, 28 ul. Vavilova, 119334, Moscow, Russian Federation

    V. S. Yufryakov, M. A. Tsvetikova, N. A. Bystrova & K. A. Kochetkov

Authors
  1. V. S. Yufryakov
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  2. M. A. Tsvetikova
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  3. N. A. Bystrova
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  4. K. A. Kochetkov
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Corresponding author

Correspondence to K. A. Kochetkov.

Additional information

This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (State Task No. 075-00697-22-00). The contribution of the Center for Molecular Composition Studies of INEOS RAS is gratefully acknowledged.

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 5, pp. 1268–1273, May, 2023.

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Yufryakov, V.S., Tsvetikova, M.A., Bystrova, N.A. et al. Chemo-enzymatic synthesis of (S,S)-2,2′-(ethylenediamino)dibutan-1-ol. Russ Chem Bull 72, 1268–1273 (2023). https://doi.org/10.1007/s11172-023-3900-4

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  • DOI: https://doi.org/10.1007/s11172-023-3900-4

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