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Reactions of highly electrophilic azolo[b]pyridines with polyphenols

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Abstract

Reactions of highly electrophilic azolo[b]pyridines with di- and triatomic phenols lead to products of 1,4-addition of C-nucleophiles to the pyridine cycle. It is found that another type of azoloazines, namely [1,2,4]triazolo[1,5-a]pyridines, are also capable to form adducts with polyphenols. Synthesized compounds containing simultaneously several pharmacophoric fragments are of interest as potential biologically active compounds.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    A. M. Starosotnikov, M. A. Bastrakov & V. A. Kokorekin

Authors
  1. A. M. Starosotnikov
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  2. M. A. Bastrakov
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  3. V. A. Kokorekin
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Corresponding author

Correspondence to A. M. Starosotnikov.

Additional information

This work was performed under financial support of the Russian Science Foundation (Project No. 19-73-20259).

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 5, pp. 1219–1224, May, 2023.

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Starosotnikov, A.M., Bastrakov, M.A. & Kokorekin, V.A. Reactions of highly electrophilic azolo[b]pyridines with polyphenols. Russ Chem Bull 72, 1219–1224 (2023). https://doi.org/10.1007/s11172-023-3892-0

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  • DOI: https://doi.org/10.1007/s11172-023-3892-0

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