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A convenient synthesis of 2-bromo-3-(morpholin-4-yl)propionic acid esters

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Abstract

A convenient one-pot synthesis of α-bromoacrylic acid esters followed by their conversion into α-bromo-substituted β-amino acid esters via Michael addition with secondary cyclic amines is proposed. Among the amines, morpholine turned most suitable.

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Authors and Affiliations

  1. Lomonosov Moscow State University, Leninskie Gory, Moscow, 119991, Russian Federation

    J. V. Kuznetsova, L. M. Petrovskaya, M. E. Kukushkin, N. V. Zyk & E. K. Beloglazkina

Authors
  1. J. V. Kuznetsova
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  2. L. M. Petrovskaya
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  3. M. E. Kukushkin
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  4. N. V. Zyk
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  5. E. K. Beloglazkina
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Corresponding authors

Correspondence to J. V. Kuznetsova or E. K. Beloglazkina.

Additional information

Dedicated to Academician of the Russian Academy of Sciences I. P. Beletskaya on the occasion of her anniversary.

The research was supported by the Council for grants of the President of the Russian Federation (Program for Supporting Young Scientists, grant MK-3748.2022.1.3).

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 4, pp. 1083–1087, April, 2023.

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Kuznetsova, J.V., Petrovskaya, L.M., Kukushkin, M.E. et al. A convenient synthesis of 2-bromo-3-(morpholin-4-yl)propionic acid esters. Russ Chem Bull 72, 1083–1087 (2023). https://doi.org/10.1007/s11172-023-3874-2

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  • DOI: https://doi.org/10.1007/s11172-023-3874-2

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