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Oxidation of 2-(5-bromo-3,4-dihydropyrimidin-4-yl)phenols, a new approach to the synthesis of benzofuro[3,2-d]pyrimidines

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Abstract

A new method for the synthesis of benzofuro[3,2-d]pyrimidines was developed based on the oxidation of 2-(5-bromo-3,4-dihydropyrimidin-4-yl)phenols followed by the intramolecular nucleophilic aromatic substitution reaction.

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Authors and Affiliations

  1. North Caucasus Federal University, 1A ul. Pushkina, 355017, Stavropol’, Russian Federation

    S. V. Shcherbakov, N. A. Aksenov, V. Yu. Shcherbakova, A. Yu. Magometov, A. Yu. Ivanova, S. N. Ovcharov & A. V. Aksenov

Authors
  1. S. V. Shcherbakov
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  2. N. A. Aksenov
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  3. V. Yu. Shcherbakova
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  4. A. Yu. Magometov
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  5. A. Yu. Ivanova
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  6. S. N. Ovcharov
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  7. A. V. Aksenov
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Corresponding author

Correspondence to N. A. Aksenov.

Additional information

Dedicated to Academician of the Russian Academy of Sciences I. P. Beletskaya on the occasion of her anniversary.

This work was financially supported by the Russian Science Foundation (Project No. 21-73-00057, https://rscf.ru/project/21-73-00057/).

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 4, pp. 966–971, April, 2023.

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Shcherbakov, S.V., Aksenov, N.A., Shcherbakova, V.Y. et al. Oxidation of 2-(5-bromo-3,4-dihydropyrimidin-4-yl)phenols, a new approach to the synthesis of benzofuro[3,2-d]pyrimidines. Russ Chem Bull 72, 966–971 (2023). https://doi.org/10.1007/s11172-023-3861-7

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  • DOI: https://doi.org/10.1007/s11172-023-3861-7

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