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Binuclear iron tetranitrosyl complexes with m- and p-methoxybenzenethiolate and naphthalene-2-thiolate ligands: synthesis, structure, and properties

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Abstract

Three new binuclear iron tetranitrosyl complexes with m- and p-methoxybenzenethiolate and naphthalene-2-thiolate ligands were synthesized. The crystals of the new complexes were characterized by X-ray diffraction, IR spectroscopy, Mössbauer spectroscopy, and elemental analysis. The synthesized complexes were evaluated for nitric oxide-donor properties, cytotoxicity against cancer and normal cell lines, and antibacterial activity. The complexes and the corresponding ligands have different toxicity in cells of different origin; in some cases, the ligands exhibit higher cytotoxicity compared to the complexes. The complexes exhibited antibacterial activity comparable to that of the antibiotic kanamycin, while the ligands did not possess antibacterial activity. The complex with the m-methoxybenzenethiolate ligand inhibits the biofilm formation of the bacteria Micrococcus luteus with an efficiency comparable to that of ampicillin and kanamycin.

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Authors and Affiliations

  1. Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation

    G. I. Kozub, T. A. Kondratieva, G. V. Shilov, A. N. Utenyshev, N. S. Ovanesyan, V. A. Mumyatova, A. A. Balakina, A. A. Terentyev, N. A. Sanina & S. M. Aldoshin

  2. National Research Center “Kurchatov Institute”, 1 ul. Akad. Kurchatova, 123182, Moscow, Russian Federation

    V. A. Lazarenko

  3. Scientific and Educational Center “Medicinal Chemistry”, Moscow Region State Pedagogical University, 24 ul. Very Voloshinoi, 141014, Mytishchi, Moscow Region, Russian Federation

    A. A. Terentyev & N. A. Sanina

  4. Department of Fundamental Physical and Chemical Engineering, M. V. Lomonosov Moscow State University, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    A. A. Terentyev & N. A. Sanina

Authors
  1. G. I. Kozub
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  2. T. A. Kondratieva
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  5. V. A. Lazarenko
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  6. N. S. Ovanesyan
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  7. V. A. Mumyatova
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  8. A. A. Balakina
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  9. A. A. Terentyev
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  10. N. A. Sanina
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  11. S. M. Aldoshin
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Corresponding author

Correspondence to N. A. Sanina.

Additional information

Dedicated to Academician of the Russian Academy of Sciences I. P. Beletskaya on the occasion of her anniversary.

This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (state assignment No. AAAA-A19-119071890015-6).

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 3, pp. 651–663, March, 2023.

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Kozub, G.I., Kondratieva, T.A., Shilov, G.V. et al. Binuclear iron tetranitrosyl complexes with m- and p-methoxybenzenethiolate and naphthalene-2-thiolate ligands: synthesis, structure, and properties. Russ Chem Bull 72, 651–663 (2023). https://doi.org/10.1007/s11172-023-3829-2

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  • DOI: https://doi.org/10.1007/s11172-023-3829-2

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