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Thevinoic acid fluoroalkyl esters

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Abstract

Reaction of thebaine with β-fluoroalkyl acrylates proceeds regioselectively and gives fluoroalkyl thevinoates, which can be used to prepare conjugates of 4,5α-epoxy-6,14-endo-ethenomorphinans with bioactive molecules.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, 28 ul. Vavilova, 119334, Moscow, Russian Federation

    I. V. Sandulenko, M. V. Zelentsova, A. A. Tyutyunov & S. K. Moiseev

Authors
  1. I. V. Sandulenko
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  2. M. V. Zelentsova
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  3. A. A. Tyutyunov
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  4. S. K. Moiseev
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Corresponding author

Correspondence to I. V. Sandulenko.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2754–2756, December, 2022.

The study was financially supported by the Russian Science Foundation (Project No. 22-23-01140).

No human or animal subjects were used in this research.

The authors declare no competing interests.

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Sandulenko, I.V., Zelentsova, M.V., Tyutyunov, A.A. et al. Thevinoic acid fluoroalkyl esters. Russ Chem Bull 71, 2754–2756 (2022). https://doi.org/10.1007/s11172-022-3705-x

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  • DOI: https://doi.org/10.1007/s11172-022-3705-x

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