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Synthesis of thiomethyl-substituted 2,6-di-tert-butylphenols via the domino reaction between thiols, N,N,N′,N′-tetraethylmethylene diamine, and 2,6-di-tert-butylphenol

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Abstract

Heating of thiols, N,N,N′,N′-tetraethylmethylene diamine, and phenols in DMF affords thiomethyl-substituted phenols in high yields. The developed procedure performed well for aliphatic, aromatic, and functionalized thiols.

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Authors and Affiliations

  1. Novosibirsk State Pedagogical University, 28 Vilyuiskaya ul., 630126, Novosibirsk, Russian Federation

    S. E. Yagunov & O. I. Prosenko

  2. Novosibirsk Research Institute of Antioxidants, 54a Krasnyi prosp., 630091, Novosibirsk, Russian Federation

    O. I. Prosenko

Authors
  1. S. E. Yagunov
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  2. O. I. Prosenko
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Corresponding author

Correspondence to S. E. Yagunov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2751–2753, December, 2022.

No human or animal subjects were used in this research.

The authors declare no competing interests.

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Yagunov, S.E., Prosenko, O.I. Synthesis of thiomethyl-substituted 2,6-di-tert-butylphenols via the domino reaction between thiols, N,N,N′,N′-tetraethylmethylene diamine, and 2,6-di-tert-butylphenol. Russ Chem Bull 71, 2751–2753 (2022). https://doi.org/10.1007/s11172-022-3704-y

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  • DOI: https://doi.org/10.1007/s11172-022-3704-y

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