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Antioxidant properties of 2,5-substituted 6H-1,3,4-thiadiazines promising for experimental therapy of diabetes mellitus

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Abstract

Antioxidant properties of synthetic 2,5-substituted 6H-1,3,4-thiadiazines were comprehensively studied using potentiometric methods based on the reactions of electron transfer (ET mechanism) and hydrogen atom transfer (HAT mechanism) from the anti-oxidant to oxidant molecule. The kinetic parameters of the reactions with various oxidizing agents were estimated taking into account peculiarities of the transformation of 2,5-substituted 6H-1,3,4-thiadiazines in solution. The relationships “structure—antioxidant properties” are established. The role of the electron-donating and electron-withdrawing properties of substituents in positions 2 and 5 of the 1,3,4-thiadiazine ring in the manifestation of antioxidant properties is examined.

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Authors and Affiliations

  1. Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Chemical Technology, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    E. L. Gerasimova, E. G. Gazizullina, D. I. Igdisanova, L. P. Sidorova, T. A. Tseitler, V. V. Emelianov, O. N. Chupakhin & A. V. Ivanova

Authors
  1. E. L. Gerasimova
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  2. E. G. Gazizullina
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  3. D. I. Igdisanova
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  4. L. P. Sidorova
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  5. T. A. Tseitler
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  6. V. V. Emelianov
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  7. O. N. Chupakhin
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  8. A. V. Ivanova
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Corresponding author

Correspondence to E. L. Gerasimova.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2730–2739, December, 2022.

This work was financially supported by the Russian Foundation for Basic Research (Project No. 19-29-08015 mk).

No human or animal subjects were used in this research.

The authors declare no competing interests.

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Gerasimova, E.L., Gazizullina, E.G., Igdisanova, D.I. et al. Antioxidant properties of 2,5-substituted 6H-1,3,4-thiadiazines promising for experimental therapy of diabetes mellitus. Russ Chem Bull 71, 2730–2739 (2022). https://doi.org/10.1007/s11172-022-3702-0

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  • DOI: https://doi.org/10.1007/s11172-022-3702-0

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