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Synthesis of purine conjugates with N-(4-aminobenzenesulfonyl)-and N-(2-aminoethanesulfonyl)-(S)-glutamic acids

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Abstract

The approaches to the synthesis of purine conjugates with N-(4-aminobenzenesulfonyl)-(S)-glutamic acid and N-(2-ammoethanesulfonyl)-(S)-glutamic acid by nucleophilic substitution of chlorine atom in 6-chloropurine derivatives have been developed. The studied compounds did not show significant antimycobacterial activity in the in vitro experiment.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoi, 620108, Yekaterinburg, Russian Federation

    A. Yu. Vigorov, E. B. Gorbunov, M. A. Ezhikova, M. I. Kodess, D. V. Belyaev, G. L. Levit & V. P. Krasnov

  2. Ural Research Institute of Phthisiopulmonology, National Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Ministry of Health of the Russian Federation, 50 ul. 22 Parts’ezda, 620039, Yekaterinburg, Russian Federation

    D. V. Belyaev & D. V. Vakhrusheva

Authors
  1. A. Yu. Vigorov
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  2. E. B. Gorbunov
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  3. M. A. Ezhikova
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  4. M. I. Kodess
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  5. D. V. Belyaev
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  6. D. V. Vakhrusheva
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  7. G. L. Levit
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  8. V. P. Krasnov
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Corresponding author

Correspondence to A. Yu. Vigorov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2685–2690, December, 2022.

This work was financially supported by the Russian Science Foundation (Project No. 19-13-00231-P).

The equipment of the Centre for Joint Use “Spectroscopy and Analysis of Organic Compounds” (CJU “SAOC”) at the Postovsky Institute of Organic Synthesis of the Russian Academy of Sciences (Ural Branch) was used in the work.

No human or animal subjects were used in this research.

The authors declare no competing interests.

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Vigorov, A.Y., Gorbunov, E.B., Ezhikova, M.A. et al. Synthesis of purine conjugates with N-(4-aminobenzenesulfonyl)-and N-(2-aminoethanesulfonyl)-(S)-glutamic acids. Russ Chem Bull 71, 2685–2690 (2022). https://doi.org/10.1007/s11172-022-3697-6

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  • DOI: https://doi.org/10.1007/s11172-022-3697-6

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