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Synthesis and evaluation of the antioxidant activity of amino derivatives of o-isobornylphenols

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Abstract

The reaction of o-isobornylphenols with bismuth(iii) nitrate provided o- and p-nitrophenols, the reduction of the nitro group of which with zinc dust in acetic acid led to the corresponding o- and p-aminophenols. A comparative evaluation of antioxidant properties was performed for the newly obtained aminophenols with an isobornyl substituent using in vitro models. It is shown that the proposed modification of o-isobornylphenols is promising for obtaining new highly active inhibitors of oxidative processes.

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Authors and Affiliations

  1. Institute of Chemistry of the Komi Science Center of the Ural Branch of the Russian Academy of Sciences, 48 ul. Pervomaiskaya, 167000, Syktyvkar, Russian Federation

    E. V. Buravlev

  2. Institute of Biology of the Komi Science Center of the Ural Branch of the Russian Academy of Sciences, 28 ul. Kommunisticheskaya, 167982, Syktyvkar, Russian Federation

    O. G. Shevchenko

Authors
  1. E. V. Buravlev
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  2. O. G. Shevchenko
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Correspondence to E. V. Buravlev.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2621–2628, December, 2022.

This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (Russian state assignment Nos 122040600073-3 and 122040600022-1).

The analysis of the synthesized compounds was partly performed using the equipment of the “Chemistry” Center for Collective Use of the Institute of Chemistry of the Komi Science Center, the Ural Branch of the Russian Academy of Sciences. The study of the activity of compounds was carried out using the equipment of the “Molecular Biology” Center for Collective Use of the Institute of Biology of the Komi Scientific Center, the Ural Branch of the Russian Academy of Sciences.

No human or animal subjects were used in this research. All studies of the activity of compounds were performed in vitro using tissues of intact laboratory mice from the scientific collection of experimental animals of the Institute of Biology of the Komi Scientific Center, the Ural Branch of the Russian Academy of Sciences (https://ckp-rf.ru/usu/471933/), which were kept in accordance with the “Regulations on the vivarium of experimental animals” (Protocol No. 1 dated January 24, 2017), complying sanitary-hygienic and bioethical requirements.

The authors declare no competing interests.

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Buravlev, E.V., Shevchenko, O.G. Synthesis and evaluation of the antioxidant activity of amino derivatives of o-isobornylphenols. Russ Chem Bull 71, 2621–2628 (2022). https://doi.org/10.1007/s11172-022-3691-z

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  • DOI: https://doi.org/10.1007/s11172-022-3691-z

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