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Reaction of 1H-pyrrole-2,3-diones with malononitrile and aminocyclohexenones: synthesis of spiro[pyrrole-3,4′-quinolines]

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Abstract

New polyhydroquinolines spiroannulated with the pyrrol-2-one moiety were synthesized by the 4-dimethylaminopyridine-catalyzed three-component reaction of 1H-pyrrole-2,3-diones with malononitrile and aminocyclohexenones. The synthesized polyhydroquinolines exhibit antioxidant activity.

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Authors and Affiliations

  1. Perm State University, 15 ul. Bukireva, 614068, Perm, Russian Federation

    M. V. Dmitriev, A. A. Moroz, A. A. Sabitov & A. N. Maslivets

Authors
  1. M. V. Dmitriev
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  2. A. A. Moroz
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  3. A. A. Sabitov
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  4. A. N. Maslivets
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Corresponding authors

Correspondence to M. V. Dmitriev or A. N. Maslivets.

Additional information

This work was financially supported by the Perm World-Class Scientific and Educational Center “Rational Subsurface Use,” 2022.

No human or animal subjects were used in this research.

The authors declare no competing interests.

Based on the materials of the VI North Caucasus Organic Chemistry Symposium NCOCS-2022 (April 18–22, 2022, Stavropol).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2441–2450, November, 2022.

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Dmitriev, M.V., Moroz, A.A., Sabitov, A.A. et al. Reaction of 1H-pyrrole-2,3-diones with malononitrile and aminocyclohexenones: synthesis of spiro[pyrrole-3,4′-quinolines]. Russ Chem Bull 71, 2441–2450 (2022). https://doi.org/10.1007/s11172-022-3672-2

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  • DOI: https://doi.org/10.1007/s11172-022-3672-2

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