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Synthesis of new conjugates of 6-thiopurine and thioguanine with (S)-glutamic acid

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Abstract

We have developed an efficient method for the synthesis of 6-thiopurine and thioguanine conjugates containing a (S)-glutamic acid residue, which is based on the reaction of 6-thio derivatives of purine with di-tert-butyl N-chloroacetyl-(S)-glutamate and subsequent hydrolysis of the ester groups.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoi, 620108, Ekaterinburg, Russian Federation

    A. A. Telegina, D. A. Gruzdev, G. L. Levit & V. P. Krasnov

Authors
  1. A. A. Telegina
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  2. D. A. Gruzdev
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  3. G. L. Levit
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  4. V. P. Krasnov
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Corresponding author

Correspondence to D. A. Gruzdev.

Additional information

This work was financially supported by the Russian Science Foundation (Project No. 19-13-00231-P). Equipment of the Centre for Joint Use “Spectroscopy and Analysis of Organic Compounds” (CJU “SAOC”) at the Postovsky Institute of Organic Synthesis of the Russian Academy of Sciences (Ural Branch) was used.

No human or animal subjects were used in this research.

The authors declare no competing interests.

Based on the materials of the VI North Caucasus Symposium on Organic Chemistry NCOCS-2022 (April 18–22, 2022, Stavropol, Russian Federation).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2426–2430, November, 2022.

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Telegina, A.A., Gruzdev, D.A., Levit, G.L. et al. Synthesis of new conjugates of 6-thiopurine and thioguanine with (S)-glutamic acid. Russ Chem Bull 71, 2426–2430 (2022). https://doi.org/10.1007/s11172-022-3670-4

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  • DOI: https://doi.org/10.1007/s11172-022-3670-4

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