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(2-Hydroxyphenyl)phosphonic acid: complexation with the copper(ii) cation, toxicity, and accumulation in HeLa cells

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Abstract

The copper(ii) complex [Cu(H2L1)2(H2O)2] with (2-hydroxyphenyl)phosphonic acid (H3L1) was synthesized. The composition and structure of the complex were determined by X-ray diffraction, elemental analysis, and IR spectroscopy. Quantum chemical calculations of the structure of the H3L1 molecule were performed by the density functional theory (DFT). The protonation constants of H3L1 and the stability constants of its complexes with Cu2+ in water were determined by potentiometric titration. The cytotoxic properties and the accumulation of the [Cu(H2L1)2(H2O)2] complex in human cervical adenocarcinoma HeLa cells were evaluated for the first time, thereby demonstrating that this complex is promising for further biological studies.

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Authors and Affiliations

  1. N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky prosp., 119991, Moscow, Russian Federation

    I. S. Ivanova, A. B. Ilyukhin & E. N. Pyatova

  2. A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Build. 4, 31 Leninsky prosp., 119071, Moscow, Russian Federation

    G. S. Tsebrikova & V. P. Solov’ev

  3. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    M. A. Lapshina, Yu. I. Rogacheva & V. E. Baulin

Authors
  1. I. S. Ivanova
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  2. G. S. Tsebrikova
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  3. M. A. Lapshina
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  4. Yu. I. Rogacheva
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  5. A. B. Ilyukhin
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  6. V. P. Solov’ev
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  7. E. N. Pyatova
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  8. V. E. Baulin
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Corresponding author

Correspondence to I. S. Ivanova.

Additional information

The work was performed within the framework of the state assignments of the N. S. Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, the A. N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences, and the Institute of Physiologically Active Compounds of the Russian Academy of Sciences and was financially supported by the Russian Science Foundation (biological studies, Project No. 22-13-00051; synthesis of ligands and quantum chemical calculations, Project No. 21-43-00020, which is implemented jointly with the National Natural Science Foundation of China (NSFC), Partner Grant No. 52061135204).

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2365–2374, November, 2022.

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Ivanova, I.S., Tsebrikova, G.S., Lapshina, M.A. et al. (2-Hydroxyphenyl)phosphonic acid: complexation with the copper(ii) cation, toxicity, and accumulation in HeLa cells. Russ Chem Bull 71, 2365–2374 (2022). https://doi.org/10.1007/s11172-022-3664-2

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  • DOI: https://doi.org/10.1007/s11172-022-3664-2

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