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Synthesis of polyfunctional trifluoromethylated pyridones fused with the strained carbocyclic cores

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Abstract

A two-step synthesis of trifluoromethylated pyridones fused with different strained carbocyclic cores was developed. Acylation of the starting cyclic amino enones with ethyl malonyl chloride gave the corresponding amido enones that underwent the intramolecular Knoevenagel condensation to afford the target fused pyridones.

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Funding

This work was financially supported by the Russian Science Foundation (Project No. 22-23-00887).

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Build. 1, 28 ul. Vavilova, 119991, Moscow, Russia

    A. B. Koldobskii, O. S. Shilova, S. A. Glazun & I. V. Sandulenko

Authors
  1. A. B. Koldobskii
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  2. O. S. Shilova
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  3. S. A. Glazun
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  4. I. V. Sandulenko
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Corresponding author

Correspondence to A. B. Koldobskii.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2224–2230, October, 2022.

No human or animal subjects were used in this research.

The authors declare no competing interests.

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Koldobskii, A.B., Shilova, O.S., Glazun, S.A. et al. Synthesis of polyfunctional trifluoromethylated pyridones fused with the strained carbocyclic cores. Russ Chem Bull 71, 2224–2230 (2022). https://doi.org/10.1007/s11172-022-3649-1

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  • DOI: https://doi.org/10.1007/s11172-022-3649-1

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