Abstract
The activity towards superoxide anion radical (O2·−) generated in an enzymatic model system upon reduction of nitro blue tetrazolium (NBT test), as well as during non-enzymatic oxidation of adrenaline in an alkaline media, was revealed for water-soluble quaternary ammonium salts bearing 2,6-di-tert-butylphenol and pyridine moiety. An increased activity of superoxide dismutase of the Russian sturgeon liver homogenate in the presence of these salts was found. A moderate Fe2+-chelating activity relative to the EDTA standard is characteristic of these salts. Their inhibitory effect was demonstrated in model systems of non-enzymatic oxidation of cis-octadec-9-enoic acid and lipids of the Russian sturgeon liver homogenate. The highest gross antioxidant activity was found for a water-soluble quaternary ammonium salt containing the ortho-pyridinyl moiety.
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Funding
This work was financially supported by the Russian Foundation for Basic Research (Project No. 20-03-00446, in parts of NBT test and adrenaline autoxidation) and by the Russian Science Foundation (Project No. 22-23-00295, in parts of FRAP-test and iron chelating activity), and carried out within the framework of State Assignment (Registration No. 122020100328-1, in parts of experiments in vitro with Russian sturgeon liver and oleic acid).
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2218–2223, October, 2022.
No human or animal subjects were used in this research.
The authors declare no competing interests.
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Polovinkina, M.A., Osipova, A.D., Osipova, V.P. et al. Evaluation of the antioxidant activity of water-soluble quaternary ammonium salts containing 2,6-di-tert-butylphenol and pyridine moieties. Russ Chem Bull 71, 2218–2223 (2022). https://doi.org/10.1007/s11172-022-3648-2
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DOI: https://doi.org/10.1007/s11172-022-3648-2