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Preparation and cytotoxic properties of porphysomes based on petroleum porphyrins

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Abstract

An approach to the preparation of porphysomes by the noncovalent immobilization of petroleum porphyrins in the liposome membranes was developed for the first time. Modified nanocontainers with different compositions were prepared in terms of this approach. A composition with doxorubicin optimal in the physicochemical and encapsulation parameters was tested on the M-HeLa cervical cancer cell line and healthy Chang Liver cell line to evaluate the anticancer potential. In order to control the release of the drug substance, remote destruction of the porphysomes was carried out by laser irradiation at 405 nm wavelength. Statistically significant changes in dynamic light scattering data confirming liposome decomposition were obtained for the compositions with 2 and 10 mol.% petroleum porphyrins.

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Authors and Affiliations

  1. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 8 ul. Akad. Arbuzova, 420088, Kazan, Russian Federation

    R. V. Pavlov, N. A. Mironov, G. A. Gaynanova, A. P. Lyubina, A. D. Voloshina, M. R. Yakubov & L. Ya. Zakharova

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  1. R. V. Pavlov
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  2. N. A. Mironov
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  3. G. A. Gaynanova
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  4. A. P. Lyubina
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  5. A. D. Voloshina
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  6. M. R. Yakubov
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  7. L. Ya. Zakharova
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Correspondence to R. V. Pavlov.

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Dedicated to Academician of the Russian Academy of Sciences V. A. Tartakovsky on the occasion of his 90th birthday.

This work was financially supported by the Russian Science Foundation (Project No. 19-73-30012).

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1992–1997, September, 2022.

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Pavlov, R.V., Mironov, N.A., Gaynanova, G.A. et al. Preparation and cytotoxic properties of porphysomes based on petroleum porphyrins. Russ Chem Bull 71, 1992–1997 (2022). https://doi.org/10.1007/s11172-022-3619-7

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  • DOI: https://doi.org/10.1007/s11172-022-3619-7

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