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Mixed micellar systems — efficient nanocontainers for the delivery of hydrophobic substrates

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Abstract

Self-organization in mixed compositions based on hexadecyltriphenylphosphonium bromide (TPPB-16) and nonionic surfactant Brij 35 was studied using a complex of physicochemical methods (tensiometry, fluorimetry, dynamic light scattering, spectrophotometry) by varying the molar fraction of cationic surfactant (α1 = 0, 0.3, 0.5, 0.7, and 1.0). The solubilization capacities of the obtained nanosized aggregates toward the model hydrophobic probe Orange OT and the drug indomethacin were calculated. The TPPB-16/Brij 35 systems demonstrate a synergistic effect, manifesting itself in a decrease of the critical micelle concentration. The obtained mixed compositions with molar fractions of 0.5 and 0.7 demonstrate solubilization capacities toward Orange OT and indomethacin comparable to those of cationic amphiphile. The formation of the mixed composition TPPB-16/Brij 35 reduces the toxicity of the system while maintaining high functional activity.

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Authors and Affiliations

  1. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”, 8 ul. Akad. Arbuzova, 420088, Kazan, Russian Federation

    L. A. Vasileva, R. F. Eyupova, F. G. Valeeva, G. A. Gaynanova & L. Ya. Zakharova

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  1. L. A. Vasileva
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  2. R. F. Eyupova
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  3. F. G. Valeeva
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  4. G. A. Gaynanova
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Correspondence to L. A. Vasileva.

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Dedicated to Academician of the Russian Academy of Sciences V. A. Tartakovsky on the occasion of his 90th birthday.

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1897–1906, September, 2022.

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Vasileva, L.A., Eyupova, R.F., Valeeva, F.G. et al. Mixed micellar systems — efficient nanocontainers for the delivery of hydrophobic substrates. Russ Chem Bull 71, 1897–1906 (2022). https://doi.org/10.1007/s11172-022-3607-y

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