Abstract
The three-component cyclization of 3-polyfluoroalkyl-3-oxopropanoates and methyl ketones with ammonium acetate affords 6-organyl-4-(polyfluoroalkyl)pyridin-2(1H)-ones (organyl is alkyl, aryl, or hetaryl). The synthesized pyridones were evaluated for antifungal, antibacterial, and analgesic activity.
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Dedicated to Academician of the Russian Academy of Sciences V. A. Tartakovsky on the occasion of his 90th birthday.
This work was financially supported by the Russian Science Foundation (Project No. 21-13-00390). Analytical studies were performed using the equipment of the Joint Use Center “Spectroscopy and Analysis of Organic Compounds” (JUC SAOC) of the I. Ya. Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences.
No human or animal subjects were used in this research.
The authors declare no competing interests.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1687–1700, August, 2022.
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Kushch, S.O., Goryaeva, M.V., Burgart, Y.V. et al. Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs. Russ Chem Bull 71, 1687–1700 (2022). https://doi.org/10.1007/s11172-022-3579-y
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DOI: https://doi.org/10.1007/s11172-022-3579-y