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Synthesis of 5-(4-bromophenyl)- and 5-(5-bromothiophen-2-yl)-substituted 3-aryl[1,2,4]triazolo[4,3-c]quinazolines

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Abstract

A series of [1,2,4]triazolo[4,3-c]quinazolines, bearing 3-positioned p-bromophenyl or 5-bromothiophen-2-yl fragment, was synthesized by oxidative cyclization of the corresponding hydrazones with bromine in glacial acetic acid at room temperature. The obtained tricyclic derivatives are valuable intermediates for biologically active compounds and fluorophores.

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Funding

The study was financially supported by the Ministry of Science and Higher Educaion of the Russian Federation (Government contract No. FEUZ-2020-0058 (H687/42B.223/20)).

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Authors and Affiliations

  1. Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 ul. Mira, 620002, Ekaterinburg, Russia

    E. V. Nosova, A. E. Kopotilova, M. A. Ivan’kina, T. N. Moshkina & D. S. Kopchuk

  2. I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 20 ul. S. Kovalevskoi, 620219, Ekaterinburg, Russia

    E. V. Nosova & D. S. Kopchuk

Authors
  1. E. V. Nosova
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  2. A. E. Kopotilova
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  3. M. A. Ivan’kina
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  4. T. N. Moshkina
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  5. D. S. Kopchuk
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Corresponding author

Correspondence to E. V. Nosova.

Additional information

Dedicated to Academician of the Russian Academy of Sciences V. I. Ovcharenko on the occasion of his 70th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1483–1487, July, 2022.

No human or animal subjects were used in this research.

The authors declare no competing interests.

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Nosova, E.V., Kopotilova, A.E., Ivan’kina, M.A. et al. Synthesis of 5-(4-bromophenyl)- and 5-(5-bromothiophen-2-yl)-substituted 3-aryl[1,2,4]triazolo[4,3-c]quinazolines. Russ Chem Bull 71, 1483–1487 (2022). https://doi.org/10.1007/s11172-022-3554-7

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  • DOI: https://doi.org/10.1007/s11172-022-3554-7

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