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Synthesis of substituted hexahydro-2H-chromeno[4,3-d]pyrimidine-2,5-diones and their modification at the hydroxy group

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Abstract

We proposed an approach for the preparation of substituted hexahydro-2H-chromeno-[4,3-d]pyrimidine-2,5-diones and studied their selective acylation and alkylation at the hydroxy group on the example of (4R*,4aS*,10bR*)-diastereomers.

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Authors and Affiliations

  1. Yaroslavl State Technical University, 88 Moskovskii prosp., 150023, Yaroslavl, Russian Federation

    E. S. Makarova, M. V. Kabanova & S. I. Filimonov

  2. K. D. Ushinsky Yaroslavl State Pedagogical University, 108/1 ul. Respublikanskaya, 150000, Yaroslavl, Russian Federation

    A. A. Shetnev

  3. G. V. Plekhanov Russian University of Economics, 36 Stremyannoy per., 117997, Moscow, Russian Federation

    K. Yu. Suponitsky

  4. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    K. Yu. Suponitsky

Authors
  1. E. S. Makarova
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  2. M. V. Kabanova
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  3. S. I. Filimonov
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  4. A. A. Shetnev
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  5. K. Yu. Suponitsky
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Corresponding authors

Correspondence to S. I. Filimonov, A. A. Shetnev or K. Yu. Suponitsky.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1034–1042, May, 2022.

K. Yu. Suponitsky is grateful to the Ministry of Science and Higher Education of the Russian Federation for financial support in carrying out structural studies.

No human or animal subjects were used in this research.

The authors declare no competing interests. References

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Makarova, E.S., Kabanova, M.V., Filimonov, S.I. et al. Synthesis of substituted hexahydro-2H-chromeno[4,3-d]pyrimidine-2,5-diones and their modification at the hydroxy group. Russ Chem Bull 71, 1034–1042 (2022). https://doi.org/10.1007/s11172-022-3505-3

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  • DOI: https://doi.org/10.1007/s11172-022-3505-3

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