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Effect of the linker nature on the antibacterial activity of structural analogs of octenidine

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Abstract

Four new octenidine analogs with different nature of the linkers between two N-octylpyridin-4-amines fragments were synthesized for the first time. The antibacterial activities of the synthesized compounds against Micrococcus luteus and Escherichia coli were studied by the method of serial dilutions using octenidine as the reference. A dependence of the antibacterial activity of the synthesized structural analogs of octenidine on the lipophilicity of dihalide used as a precursor of the linker was found: the higher the lipophilicity of the linker fragment, the lower the minimum inhibitory concentration of the compound.

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Authors and Affiliations

  1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation

    I. K. Yakushchenko, N. N. Pozdeeva, A. A. Terentiev & S. Y. Gadomsky

  2. Lomonosov Moscow State University, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    A. A. Terentiev

  3. Scientific Educational Center “Medicinal Chemistry”, Moscow Region State University, 24 ul. Very Voloshinoi, 141014, Mytishchi, Moscow Region, Russian Federation

    A. A. Terentiev

Authors
  1. I. K. Yakushchenko
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  2. N. N. Pozdeeva
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  3. A. A. Terentiev
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  4. S. Y. Gadomsky
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Corresponding author

Correspondence to S. Y. Gadomsky.

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The authors declare no competing interests.

Additional information

This work was carried out in framework of State Assignment of the Ministry of Science and Higher Education of the Russian Federation for the Institute of Problems of Chemical Physics of the Russian Academy of Sciences according to the theme “Design and Basic Research of the Structures, Properties, and Mechanisms of Biological Effect of New Small Molecules and Supramolecular Systems for the Development of Innovative Target Drugs for the Treatment of Socially Significant Diseases” (state registration No. AAAA-A19-119071890015-6). The studies were conducted using the equipment of the Analytical Center for Collective Use at the Institute of Problems of Chemical Physics of the Russian Academy of Sciences.

No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 595–597, March, 2022.

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Yakushchenko, I.K., Pozdeeva, N.N., Terentiev, A.A. et al. Effect of the linker nature on the antibacterial activity of structural analogs of octenidine. Russ Chem Bull 71, 595–597 (2022). https://doi.org/10.1007/s11172-022-3456-8

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  • DOI: https://doi.org/10.1007/s11172-022-3456-8

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