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Porous matrixes based on polyvinylpyrrolidone containing calcium phosphates for medical application

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Abstract

A number of materials based on biocompatible polymers (polyvinylpyrrolidone and sodium alginate) with hydroxyapatite and dicalcium phosphate dihydrate were developed. The properties of prepared materials were studied by IR and EPR spectroscopies depending on the composition and method of synthesis of calcium phosphates. The introduction of calcium phosphates into the polymer matrix was found to decrease the material porosity from 60–70 to 40–45 vol.% and to decrease the material swelling from 250 to 150%. The results of EPR spectroscopy showed that polyvinylpyrrolidone does not affect the calcium phosphates formation in the synthesis of calcium phosphates in situ. In vitro studies suggest that a composition containing polyvinylpyrrolidone and sodium alginate in a ratio of 1 : 1 obtained ex situ is preferable in connection with its good biocompartability and an absence of cytotoxicity. This material is promising for the application in medicine.

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Authors and Affiliations

  1. A. A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, 49 Leninsky prosp., 119991, Moscow, Russian Federation

    I. V. Fadeeva, A. A. Forysenkova, O. S. Antonova & S. M. Barinov

  2. M. V. Lomonosov Moscow State University, 1 Leninskie gory, 119991, Moscow, Russian Federation

    E. S. Trofimchuk

  3. Kazan Federal University, 18 Kremlevskaya ul., 420008, Kazan, Russian Federation

    M. R. Gafurov & A. I. Ahmed

  4. Department of Physics, University of Al-Hamadaniya, Mosul, 41001, Iraq

    A. I. Ahmed

  5. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 3 Institutskaya ul., 142290, Pushchino, Moscow region, Russian Federation

    G. A. Davidova

Authors
  1. I. V. Fadeeva
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  2. A. A. Forysenkova
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  3. E. S. Trofimchuk
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  4. M. R. Gafurov
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  5. A. I. Ahmed
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  6. G. A. Davidova
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  7. O. S. Antonova
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  8. S. M. Barinov
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Correspondence to I. V. Fadeeva.

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The authors declare no competing interests.

Additional information

The work was performed in the frameworks of state assignment (Topic No. 075-00328-21-00).

Research by the EPR method was carried out with the financial support of budget funding in the field of scientific activity allocated to Kazan Federal University (Project No. 0671-2020-0051).

In vitro studies of materials were carried out as part of the state assignment (Topic No. 075-00381-21-00).

No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 543–548, March, 2022.

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Fadeeva, I.V., Forysenkova, A.A., Trofimchuk, E.S. et al. Porous matrixes based on polyvinylpyrrolidone containing calcium phosphates for medical application. Russ Chem Bull 71, 543–548 (2022). https://doi.org/10.1007/s11172-022-3446-x

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  • DOI: https://doi.org/10.1007/s11172-022-3446-x

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