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Hydrophilic sulfur-containing antioxidant sodium 3-(3-tert-butyl-4-hydroxyphenyl)propylthiosulfate as a modulator of the activity of antitumor cytostatics and their combinations with a NO donor

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Abstract

The interaction of a combination of a sulfur-containing phenolic antioxidant sodium 3-(3-tert-butyl-4-hydroxyphenyl)propylthiosulfate (TS-13) with a nitric oxide donor (NaNO2) and two antitumor cytostatics, cisplatin and doxorubicin, was studied in vivo using a model of P-388 murine leukemia of BDF1 mice. It has been shown that the type of cytostatics used determines the efficiency of chemotherapy. Depending on this, the antioxidant TS-13 can both enhance and reduce the antitumor effect. The use of TS-13 and a nitric oxide donor with different cytostatics and different modes of drug administration modulates their activity in different ways, namely, from increasing survival to inhibition of survival.

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Authors and Affiliations

  1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation

    T. N. Bogatyrenko, T. E. Sashenkova, U. Yu. Allayarova & D. V. Mishchenko

  2. Novosibirsk State Pedagogical University, 28 ul. Vilyuyskaya, 630126, Novosibirsk, Russian Federation

    N. V. Kandalintseva

Authors
  1. T. N. Bogatyrenko
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  2. N. V. Kandalintseva
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  3. T. E. Sashenkova
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  4. U. Yu. Allayarova
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  5. D. V. Mishchenko
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Corresponding authors

Correspondence to T. N. Bogatyrenko or N. V. Kandalintseva.

Additional information

The work was performed in the frameworks of state assignment (No. AAAA-A19_119071890015-6).

All experiments involving animals and their maintenance complied with the rules of laboratory practice set in the European Convention for the Protection of Vertebrate Animals used for experiments or for other scientific purposes ETS No. 123 (Strasbourg, 1986), Order of the Ministry of Health of the Russian Federation No. 199n of 04/01/2016 “On Approval of the Rules of Good Laboratory Practice” (GLP) in compliance with the International Recommendations of the European Convention for the Protection of Vertebrate Animals Used in Experimental Research (1997).

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 517–523, March, 2022.

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Bogatyrenko, T.N., Kandalintseva, N.V., Sashenkova, T.E. et al. Hydrophilic sulfur-containing antioxidant sodium 3-(3-tert-butyl-4-hydroxyphenyl)propylthiosulfate as a modulator of the activity of antitumor cytostatics and their combinations with a NO donor. Russ Chem Bull 71, 517–523 (2022). https://doi.org/10.1007/s11172-022-3442-1

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  • DOI: https://doi.org/10.1007/s11172-022-3442-1

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