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Evaluation of antiradical activity of Schiff bases

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Abstract

Antioxidant activity of seven Schiff bases (SBs) was studied. The antiradical activity of SBs was determined by the chemiluminescence method from the interception of peroxyl radicals in the model reaction of initiated oxidation of ethylbenzene. The mechanism of inhibition of chain oxidation by SBs is poorly studied, but the addition of peroxyl radicals to the carbon atom with the disclosure of the conjugated double bond of the aldimine group -CH=N- seems to be most probable. This mechanism can be predominant one and determining the reactivity of SBs in the reaction with the rate constant (kinh): RO2• + [-CH=N-]→[-CH(RO2)-N•-]. 3-Hydroxy-2-(N-phenyliminomethyl)benzo[b]thiophene and its dimer manifested high anti-oxidant activity, and their inhibition activity is 3.43 • 105 and 7.5 • 105 L mol−1 s−1, respectively.

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Authors and Affiliations

  1. Federal Research Center of Chemical Physics named after N. N. Semenov of the Russian Academy of Sciences, 4 ul. Kosygina, 119991, Moscow, Russian Federation

    I. F. Rusina & L. A. Smurova

  2. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 119334, Moscow, Russian Federation

    T. L. Veprintsev

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  1. I. F. Rusina
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  2. L. A. Smurova
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  3. T. L. Veprintsev
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Correspondence to I. F. Rusina, L. A. Smurova or T. L. Veprintsev.

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Dedicated to blessed memory of Professor V. P. Litvinov.

This work was carried out in terms of state assignment of the Federal Agency of Scientific Organization of Russia (Nos 0082-2018-0006, AAAA-A18-118020890097-1, and 0084-2014-0004) registered at the Center of Information Technologies and Systems of Executive Power Authority (No. 01201-253-310).

No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 502–507, March, 2022.

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Rusina, I.F., Smurova, L.A. & Veprintsev, T.L. Evaluation of antiradical activity of Schiff bases. Russ Chem Bull 71, 502–507 (2022). https://doi.org/10.1007/s11172-022-3440-3

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  • DOI: https://doi.org/10.1007/s11172-022-3440-3

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