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Synthesis and properties of fluorinated uracils as promising drugs for medicine

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Russian Chemical Bulletin Aims and scope

Abstract

5-Fluorouracil is a well-known and widely used drug in medical practice for the treatment of cancer. However, there is no analytical review in the literature on the synthesis of 5-fluorouracil and its prodrugs, the properties of these compounds and the factors affecting their metabolism. In the present mini review, we made an attempt to summarize and analyze available material on these issues.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences, 71 prosp. Oktyabrya, 450054, Ufa, Russia

    I. B. Chernikova & M. S. Yunusov

Authors
  1. I. B. Chernikova
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  2. M. S. Yunusov
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Correspondence to I. B. Chernikova.

Additional information

Dedicated to Academician of the Russian Academy of Sciences O. M. Nefedov on the occasion of his 90th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 1–5, January, 2022.

The work was carried out in the framework of the Russian state assignment to the Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences “Synthesis of biologically active heterocyclic and terpenoid compounds” (Research theme AAAA-A20-120012090026-9, Registration number 0246-2019-0027).

No human or animal subjects were used in this research.

The authors declare no competing interests.

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Chernikova, I.B., Yunusov, M.S. Synthesis and properties of fluorinated uracils as promising drugs for medicine. Russ Chem Bull 71, 1–5 (2022). https://doi.org/10.1007/s11172-022-3370-0

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  • DOI: https://doi.org/10.1007/s11172-022-3370-0

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