Abstract
Some new derivatives based on 2,6-diisobornylphenol and containing amine moieties of the pinane structure at the para-position relative to the phenolic hydroxy group were synthesized. The antioxidant properties of the obtained compounds were estimated using various in vitro models. The introduction of diamine moiety into a starting molecule led to a significant increase in the radical scavenging activity and the ability to chelate Fe2+ ions.
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This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (State Assignments Nos AAAA-A21-121011190042-0 and AAAA-A18-118011120004-5).
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Dedicated to Academician of the Russian Academy of Sciences O. M. Nefedov on the occasion of his 90th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2185–2188, November, 2021.
Some analyses of the synthesized compounds were performed using the equipment of the “Chemistry” Center for Collective Use at the Institute of Chemistry of Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences. The evaluation (in vitro) of biological activities of compounds was performed using the equipment of the “Molecular Biology” Center for Collective Use at the Institute of Biology of Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences. The laboratory animals were obtained from the scientific collection of experimental animals at the same Institute (http://www.ckp-rf.ru/usu/471933/), which were handled in accordance with the “Regulations on the vivarium of experimental animals” (Protocol No. 1 dated 01.24.2017) taking into account sanitary-hygienic and bioethical aspects.
The authors declare no competing interests.
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Dvornikova, I.A., Buravlev, E.V., Shevchenko, O.G. et al. Synthesis and evaluation of the antioxidant properties for some novel aminomethyl derivatives of 2,6-diisobornylphenol bearing a pinane moiety. Russ Chem Bull 70, 2185–2188 (2021). https://doi.org/10.1007/s11172-021-3330-0
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DOI: https://doi.org/10.1007/s11172-021-3330-0