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Complex of tris(2-hydroxyethyl)amine with zinc bis(2-methylphenoxyacetate) as an inhibitor of the acid lipase of the aortic intima

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Abstract

The previously unknown ability of Zitrimin, the complex of tris(2-hydroxyethyl)amine with zinc(ii) bis(2-methylphenoxyacetate), to affect the activity of acid lipase of the aortic intima was studied. Daily administration of an aqueous solution of the tris(2-hydroxyethyl)amine complex with zinc bis(2-methylphenoxyacetate) in a dose of 10 mg kg−1 for 3 months to rabbilts with experimental atherosclerosis was found to decrease the cholesterol and total lipid levels in the aortic tissue and to decrease the degree of aortic damage with atherosclerotic plaques. According to the results of enzymatic analysis, development of atherosclerosis is accompanied by 68% increase in the activity of acid lipase in the intima of the aorta compared to the control.

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Authors and Affiliations

  1. State Scientific Research Institute of Chemistry and Technology of Organoelement Compounds, 38 sh. Entuziastov, 105118, Moscow, Russian Federation

    P. A. Storozhenko & M. M. Rasulov

  2. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 119334, Moscow, Russian Federation

    I. V. Zhigacheva

Authors
  1. P. A. Storozhenko
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  2. I. V. Zhigacheva
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  3. M. M. Rasulov
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Corresponding authors

Correspondence to I. V. Zhigacheva or M. M. Rasulov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1418–1420, July, 2021.

The authors declare no competing interests.

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Storozhenko, P.A., Zhigacheva, I.V. & Rasulov, M.M. Complex of tris(2-hydroxyethyl)amine with zinc bis(2-methylphenoxyacetate) as an inhibitor of the acid lipase of the aortic intima. Russ Chem Bull 70, 1418–1420 (2021). https://doi.org/10.1007/s11172-021-3234-z

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  • DOI: https://doi.org/10.1007/s11172-021-3234-z

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