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Sodium alginate and carbopol microcapsules: preparation, polyphenol encapsulation and release efficiency

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Abstract

An approach for the preparation of a polymer delivery system consisting of sodium alginate (SA) and carbopol was developed. The efficiency of the inclusion of medicinal compounds in these systems was investigated using the polyphenols curcumin and resveratrol as examples. Curcumin and resveratrol possess anti-inflammatory, antitumor, and antibacterial effects, which makes them promising compounds for use in clinical practice. The main disadvantage of these polyphenols is their low bioavailability. The formation of microcapsules occurs due to the precipitation of a mixture of SA and carbopol (carbopol 940 or ETD 2020), containing a model object, in a calcium chloride solution. The dependence of the inclusion of drugs in microcapsules and their release into gastrointestinal environment imitators on the viscosity characteristics of carbopol, which is part of the microcapsule shell, was investigated.

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Authors and Affiliations

  1. Research Institute of Hygiene, Occupational Pathology, and Human Ecology of the Federal Medical Biological Agency of Russia, Korp. 93, st. Kapitolovo, 188663 p.g.t. Kuz’molovskii, Vsevolozhskii r-n, Leningrad Region, Kuzmolovsky, Russian Federation

    E. V. Popova & A. S. Radilov

  2. National Research University ITMO, 49 Kronverkskii prosp., 197101, St. Petersburg, Russian Federation

    P. V. Morozova & M. V. Uspenskaya

Authors
  1. E. V. Popova
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  2. P. V. Morozova
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  3. M. V. Uspenskaya
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  4. A. S. Radilov
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Correspondence to E. V. Popova.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1335–1340, July, 2021.

This paper does not contain descriptions of studies on animals or humans.

The authors declare no competing interests.

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Popova, E.V., Morozova, P.V., Uspenskaya, M.V. et al. Sodium alginate and carbopol microcapsules: preparation, polyphenol encapsulation and release efficiency. Russ Chem Bull 70, 1335–1340 (2021). https://doi.org/10.1007/s11172-021-3220-5

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  • DOI: https://doi.org/10.1007/s11172-021-3220-5

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